Molecular subtyping of hypertensive disorders of pregnancy

Molecular subtyping of hypertensive disorders of pregnancy

Blog Article

Abstract Hypertensive disorders of pregnancy (HDP), including preeclampsia, affect 1 in 6 pregnancies, are major contributors to maternal morbidity and mortality, yet lack precision medicine strategies.Analyzing transcriptomic data from a prospectively-collected diverse cohort (n = 9102), this study reveals AquaVac 500 Parts distinct RNA subtypes in maternal blood, reclassifying clinical HDP phenotypes like early/late-onset preeclampsia.The placental gene PAPPA2 strongly predicts the most severe forms of preeclampsia in individuals without pre-existing high risk factors, months before symptoms, and its overexpression correlates with earlier delivery Wax Lift PCB Board in a dose-dependent manner.Further, molecular subtypes characterized by immune genes are upregulated in less severe forms of HDP.These results reclassify HDP clinical phenotypes into two distinct molecular subtypes, placental-associated or immune-associated.

Validation performance for placental-associated HDP yields an AUC of 0.88 in the advanced maternal age population without pre-existing high risk factors.Molecular subtypes create new opportunities to apply precision-based medicine in maternal health.